Skip to site content

Clinical Information Guidelines

Teepees at sunset by Velonia Hardy

HIV/AIDS treatment and care require knowledge of accepted guidelines as disease-specific competence is a priority. Therefore, locating clinical guidelines for treatment and care is a critical component of quality health care. Health professionals who serve on HIV treatment and care teams can follow the links below to HIV/AIDS diagnosis, treatment, and prevention guidelines.

IHS HIV Primary Care Treatment Guidelines for Adults and Adolescents – January 2021 [PDF -687 KB]

Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV Exit Disclaimer: You Are Leaving www.ihs.gov  [PDF - 21 MB] – HIVinfo.nih.gov

Guidelines for Screening and Management of Hepatitis C Virus (HCV) [PDF - 316 KB]

HIV Infection: Detection, Counseling, and Referral, 2015 Sexually Transmitted Diseases Treatment Guidelines Exit Disclaimer: You Are Leaving www.ihs.gov  - HIV screening recommendations for those who seek evaluation and treatment for STDs

HIV Prevention (DHHS) Exit Disclaimer: You Are Leaving www.ihs.gov  - Updated Guidelines for Antiretroviral Post-exposure Prophylaxis After Sexual, Injection Drug Use, or Other Non-occupational Exposure to HIV—United States, 2016

IHS Pre-Exposure Prophylaxis (PrEP) Guidelines Template [PDF - 136 KB]

Opportunistic Infections Guidelines for Adults and Adolescents Exit Disclaimer: You Are Leaving www.ihs.gov 
Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents

Opportunistic Infections Guidelines for Pediatric Patients Exit Disclaimer: You Are Leaving www.ihs.gov 
Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Exposed and HIV-Infected Children

Pediatric Guidelines Exit Disclaimer: You Are Leaving www.ihs.gov 
Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection

Perinatal Guidelines Exit Disclaimer: You Are Leaving www.ihs.gov 
U.S. Public Health Service Task Force Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV-1 Transmission in the United States

Pre-Exposure Prophylaxis (PrEP) for the Prevention of HIV Infection in the United States (2021 Update) – Clinical Practice Guideline [PDF - 1.8 MB] Exit Disclaimer: You Are Leaving www.ihs.gov - This version updates the review of scientific evidence on the safety and efficacy of antiretroviral HIV PrEP. In addition, this update includes guidance for recommended initial and follow-up STI screening, revised HIV testing strategies, and recommended primary care practices for patients prescribed oral or injectable PrEP.

Post-Exposure Prophylaxis (Occupational) Exit Disclaimer: You Are Leaving www.ihs.gov  - Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Postexposure Prophylaxis

Post-Exposure Prophylaxis (Occupational) Exit Disclaimer: You Are Leaving www.ihs.gov  - Recommendations for HIV prevention with adults and adolescents with HIV in the United States, 2014 (amended 2016)

Testing – Revised CDC HIV Screening Guidelines Exit Disclaimer: You Are Leaving www.ihs.gov 
Revised Recommendations for HIV Testing of Adults, Adolescents, and Pregnant Women in Health-Care Settings – September 22, 2006