Clinical Information Guidelines

HIV/AIDS treatment and care require knowledge of accepted guidelines as disease-specific competence is a priority. Therefore, locating clinical guidelines for treatment and care is a critical component of quality health care. Health professionals who serve on HIV treatment and care teams can follow the links below to HIV/AIDS diagnosis, treatment, and prevention guidelines.
IHS HIV Primary Care Treatment Guidelines for Adults and Adolescents – January 2021 [PDF -687 KB]
Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV [PDF - 21 MB] – HIVinfo.nih.gov
Guidelines for Screening and Management of Hepatitis C Virus (HCV) [PDF - 316 KB]
HIV Infection: Detection, Counseling, and Referral, 2015 Sexually Transmitted Diseases Treatment Guidelines - HIV screening recommendations for those who seek evaluation and treatment for STDs
HIV Prevention (DHHS) - Updated Guidelines for Antiretroviral Post-exposure Prophylaxis After Sexual, Injection Drug Use, or Other Non-occupational Exposure to HIV—United States, 2016
IHS Pre-Exposure Prophylaxis (PrEP) Guidelines Template [PDF - 136 KB]
Opportunistic Infections Guidelines for Adults and Adolescents
Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents
Opportunistic Infections Guidelines for Pediatric Patients
Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Exposed and HIV-Infected Children
Pediatric Guidelines
Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection
Perinatal Guidelines
U.S. Public Health Service Task Force Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV-1 Transmission in the United States
Pre-Exposure Prophylaxis (PrEP) for the Prevention of HIV Infection in the United States (2021 Update) – Clinical Practice Guideline [PDF - 1.8 MB] - This version updates the review of scientific evidence on the safety and efficacy of antiretroviral HIV PrEP. In addition, this update includes guidance for recommended initial and follow-up STI screening, revised HIV testing strategies, and recommended primary care practices for patients prescribed oral or injectable PrEP.
Post-Exposure Prophylaxis (Occupational) - Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Postexposure Prophylaxis
Post-Exposure Prophylaxis (Occupational) - Recommendations for HIV prevention with adults and adolescents with HIV in the United States, 2014 (amended 2016)
Testing – Revised CDC HIV Screening Guidelines
Revised Recommendations for HIV Testing of Adults, Adolescents, and Pregnant Women in Health-Care Settings – September 22, 2006