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National Core Formulary

The IHS National Core Formulary represents the basic standard of care drugs which must be carried by all federal facilities to generally promote the parity, portability, quality, safety, convenience, and cost-effectiveness of the pharmacy benefit.

  • It establishes the "floor" for the pharmacy benefit.
  • Except in closed classes, facilities are expected to add other drugs to the local formulary as needed.
Last Updated: 05/10/2021
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The following is a list of Medications currently in the queue. 212 record(s) found.
The following is a list of Medications currently in the queue. 212 record(s) found.
MedicationPharmacological CategoryFormulary BriefNotesSimilar Medications
Albuterol, metered dose inhaler (MDI) Beta2 Agonist NPTC Meeting Update (Nov 2017) *Any product*
Albuterol nebulized solution Beta2 Agonist
Alendronate Bisphosphonate Derivative Osteoporosis (2016)
Allopurinol Antigout Agent; Xanthine Oxidase Inhibitor Gout (2016)
Acetaminophen Analgesic, Miscellaneous
Anastrozole Antineoplastic Agent, Aromatase Inhibitor
Aspirin Antiplatelet Agent; Nonsteroidal Anti-Inflammatory Drug; Salicylate
Calcium Electrolyte supplement *Any formulation*
Clindamycin, topical ===REMOVED from NCF=== (See Benzoyl Peroxide AND Clindamycin, topical combination) Removed January 2020
Cyanocobalamin (Vitamin B12), oral Vitamin, Water Soluble Hematologic Supplements (2016)
Digoxin Antiarrhythmic Agent, Miscellaneous; Cardiac Glycoside Digoxin Use (2016)
Donepezil Acetylcholinesterase Inhibitor (Central) 5mg and 10mg strengths
Estradiol tablets Estrogen Derivative Menopausal Hormone Therapy (2016)
Ethinyl estradiol / Etonogestrel vaginal ring Contraceptive; Estrogen and Progestin Combination Contraception (2016)
Ethinyl estradiol / Norelgestromin, transdermal Contraceptive; Estrogen and Progestin Combination Contraception (2016)
Fibric Acid Derivative ===REMOVED from NCF=== Hyperlipidemia (2017) Removed Feb 2017
Finasteride 5 Alpha-Reductase Inhibitor Benign Prostatic Hypertrophy (2016)
Fluoride, oral Nutritional Supplement Supplements in Oral Health (2016) *Any oral formulation*
Folic Acid Vitamin, Water Soluble Supplements in Womens Health (2016) Any product containing >400 mcg / daily dose
Furosemide Antihypertensive; Loop Diuretic Heart Failure Overview (2017)
Gabapentin Anticonvulsant, Miscellaneous; GABA Analog Gabapentin & Pregabalin in Pain (2014)
Gemfibrozil ===REMOVED from NCF=== Dyslipidemia Guidelines Review (2014) Removed Feb 2014
Glipizide Antidiabetic Agent; Sulfonylurea Sulfonylureas (2015)
Glucagon Antidote; Hypoglycemia For outpatient use
H1 Antagonist (2nd generation), long-acting Histamine H1 Antagonist, Second Generation *Any product*
Insulin aspart (NovoLog®) Insulin, Rapid-Acting Insulins (2015) *Branded product*; Pen Device
Insulin aspart / Insulin aspart protamine (NovoLog® Mix 70/30) Insulin, Combination (70/30 Mix) Insulins (2015) *Branded product*; Pen Device
Insulin NPH (NovoLIN® N) Insulin, Intermediate-Acting Insulins (2015) *Branded product*
Insulin NPH / Regular human insulin (NovoLIN® 70/30) Insulin, Combination (70/30 Mix) Insulins (2015) *Branded product*
Insulin / Regular human (NovoLIN® R) Insulin, Short-Acting Insulins (2015) *Branded product*
Corticosteroid, intranasal Intranasal Corticosteroid *Any product*
Iron, oral Iron Salt Hematologic Supplements (2016) *Any oral formulation*
Laxative, bulk-forming Bulk-forming Laxative *Any product*
Laxative, stimulant Stimulant Laxative *Any product*
Letrozole Antineoplastic Agent, Aromatase Inhibitor
Levothyroxine Thyroid Agent
Lisinopril Antihypertensive, Angiotensin-Converting Enzyme Inhibitor ACEIs & ARBs in Heart Failure (2017)
Lithium Antimanic Agent ER Lithium & Divalproex (2012)
Losartan Antihypertensive, Angiotensin II Receptor Blocker ACEIs & ARBs in Heart Failure (2017)
Low-molecular weight heparin Low-molecular Weight Heparin VTE Prophylaxis (2011) *Any product*
Metformin Antidiabetic Agent; Biguanide
Mometasone (Asmanex®) Corticosteroid, Inhalant *Branded product*
Montelukast Leukotriene Receptor Antagonist
Naloxone Antidote; Opioid Antagonist Treatment of Opioid Overdose (2014)
Niacin extended release (Niaspan®) ===REMOVED from NCF=== Hyperlipidemia (2017) Removed Feb 2017
Ophthalmic Prostaglandin Analog Ophthalmic Prostaglandin Analog Ophth Prostaglandin Analogs (2018) *Any product*
Oral contraceptive pill, extended cycle Contraceptive Contraception (2016) *Any product*
Pioglitazone Antidiabetic Agent, Thiazolidinedione Thiazolidinediones (2017)
Prednisone Corticosteroid, Systemic
Proton Pump Inhibitor Proton Pump Inhibitor GERD & PUD (2018) *Any product*
Pyridoxine (Vitamin B6) Vitamin, Water Soluble Supplements in Obstetrics (2016)
Salmeterol (Serevent®) ===REMOVED from NCF=== Inhaled Anticholinergics (2011) Removed Sept 2011
Salsalate Salicylate
Spironolactone Antihypertensive; Mineralocorticoid Receptor Antagonists; Potassium Sparing Diuretic Mineralocorticoid Receptor Antagonist in HF (2017)
Sumatriptan Antimigraine Agent; Serotonin 5-HT 1B/1D Receptor Agonist Triptans (2016) Any two (2) triptan medications are required, one must be sumatriptan
Tamoxifen Antineoplastic Agent, Estrogen Receptor Antagonist; Selective Estrogen Receptor Modulator
Tiotropium (Spiriva®) Long-Acting Anticholinergic Agent Inhaled Anticholinergics (2011) *Branded product*
Trazodone ===REMOVED from NCF=== Insomnia (2015) Removed Oct 2015
Tretinoin, topical Topical Skin Product, Acne Acne (2013) *Any product*
Vaccines, All ACIP-recommended Vaccines Vaccine (2011) All ACIP recommended vaccines for routine use in accordance with ACIP guidelines
Vitamin D Vitamin D Analog Vitamin D (2010) *Any product*
Vitamin D Analog (Topical) Vitamin D Analog Psoriasis (2018) *Any product*
Loperamide Antidiarrheal Irritable Bowel Syndrome (2018)
Dicyclomine Anticholinergic Agent Irritable Bowel Syndrome (2018)
Phentermine Central Nervous System Stimulant Obesity Treatment (2018)
Phosphodiesterase 5 (PDE5) Inhibitor Phosphodiesterase-5 Enzyme Inhibitor Phosphodiesterase 5 Inhibitors (2018) *Any product*
Naltrexone, extended-release for injection (**REMS drug**) Antidote; Opioid Antagonist Opioid Use Disorder (2018) **See REMS here** Exit Disclaimer: You Are Leaving www.ihs.gov 
Buprenorphine (**REMS drug**) Analgesic, Opioid; Analgesic, Opioid Partial Agonist Opioid Use Disorder (2018) For treatment of Opioid Use Disorder in pregnant patients; **See REMS here** Exit Disclaimer: You Are Leaving www.ihs.gov 
Alogliptin Antidiabetic Agent, Dipeptidyl Peptidase 4 (DPP-4) Inhibitor DPP-IV Inhibitors (2019)
Memantine N-Methyl-D-Aspartate (NMDA) Receptor Antagonist
Carbidopa-Levodopa (immediate release) Anti-Parkinson Agent; Decarboxylase Inhibitor-Dopamine Precursor Parkinson's Disease (2019)
Ezetimibe Antilipemic Agent, 2-Azetidinone 2018 ACC/AHA Cholesterol Guidelines (2019)
Empagliflozin Antidiabetic Agent, Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor SGLT-2 Inhibitors (2019)
Liraglutide or semaglutide Antidiabetic Agent, Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist GLP-1 Receptor Agonists (2019) Select either of these subcutaneous agents, no preference given
Oseltamivir Antiviral Agent; Neuraminidase Inhibitor Treatment of Influenza (2019)
Semaglutide or liraglutide Antidiabetic Agent, Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist GLP-1 Receptor Agonists (2019) Select either of these subcutaneous agents, no preference given
Epinephrine Injection Devices (both 0.15mg and 0.3mg) Alpha-/Beta- Agonist Epinephrine Injection Devices (2020 Any device, auto-injector or pre-filled syringe
Dulaglutide ===REMOVED from NCF=== NPTC Meeting Update (2020) Removed Nov 2020
Ondansetron Antiemetic; Selective 5-HT3 Receptor Antagonist Antiemetic Agents (2021)
Prenatal Multivitamin Vitamin **COMING SOON** Must contain >400 mcg of folic acid/dose
Azithromycin Antibiotic, Macrolide **COMING SOON**
Doxycycline Antibiotic, Tetracycline **COMING SOON**
Penicillin G benzathine Antibiotic, Penicillin **COMING SOON**
Etanercept -OR- Adalimumab (can choose either product) Antirheumatic, Disease Modifying; Tumor Necrosis Factor (TNF) Blocking Agent TNF Inhibitors (2016) ONLY In consultation with a rheumatologist Adalimumab -OR- Etanercept (can choose either product)
Ipratropium, MDI ===REMOVED from NCF=== COPD Inhalers (2015) Removed Aug 2015 Albuterol, metered dose inhaler (MDI); Tiotropium (Spiriva®)
Saxagliptin ===REMOVED from NCF=== (see Alogliptin) DPP-IV Inhibitors (2019) Removed Feb 2019 Alogliptin
Nortriptyline Antidepressant, Tricyclic Antidepressants in Pain Mgmt (2014) Amitriptyline
Nifedipine (controlled or extended release) ===REMOVED from NCF=== (see Amlodine) Calcium Channel Blockers (2014) Removed August 2014 Amlodipine
Diltiazem Antihypertensive; Calcium Channel Blocker, Nondihydropyridine Calcium Channel Blockers (2014) Amlodipine
Warfarin Anticoagulant; Vitamin K Antagonist Direct Oral Anticoagulants (2017) Apixaban; Low-molecular weight heparin
Haloperidol decanoate Antipsychotic, Typical (First Generation) - Injectable Long-Acting Injectable Antipsychotics (2020) Injectable Aripiprazole lauroxil
Atypical antipsychotic Antipsychotic, Atypical Atypical Antipsychotic Agents (2015) *Any product* Aripiprazole lauroxil; Haloperidol decanoate
Clopidogrel Antiplatelet Agent Antiplatelets (2015) Aspirin
Propranolol Antihypertensive; Beta-Blocker, Non-Selective Beta Blockers (2014) Atenolol; Metoprolol
Carvedilol Antihypertensive; Beta-Blocker with Alpha-Blocking Activity Beta-blockers in Heart Failure (2017) *Immediate-release only Atenolol; Metoprolol; Propranolol
Metoprolol Antihypertensive; Beta-Blocker, Beta1 Selective Beta-blockers in Heart Failure (2017) Atenolol; Propranolol
Simvastatin Antilipemic Agent, HMG-CoA Reductase Inhibitor Dyslipidemia Guideline Review (2014) Atorvastatin; Pravastatin; Rosuvastatin
Lovastatin ===REMOVED from NCF=== (see Atorvastatin, Pravastatin, Rosuvastatin, Simvastatin) Dyslipidemia Guidelines Review (2014) Removed April 2012 Atorvastatin; Pravastatin; Rosuvastatin; Simvastatin
Rosuvastatin Antilipemic Agent, HMG-CoA Reductase Inhibitor Hyperlipidemia (2017) Atorvastatin; Pravastatin; Simvastatin
Pravastatin Antilipemic Agent, HMG-CoA Reductase Inhibitor Hyperlipidemia (2017) Atorvastatin; Rosuvastatin; Simvastatin
Benzoyl Peroxide AND Clindamycin, topical combination Topical Skin Product, Acne; Topical Skin Product, Acne (Lincosamide Antibiotic) Acne Treatment (2020) Benzoyl Peroxide
Benzoyl Peroxide Topical Skin Product, Acne Acne Treatment (2020) Benzoyl Peroxide AND Clindamycin, topical combination
Dolutegravir/abacavir/lamivudine Antiretroviral, Integrase Inhibitor (Anti-HIV) HIV Treatment (2019) *Note: HLA B5701 testing required prior to initiation Bictegravir/emtricitabine/tenofovir alafenamide; Dolutegravir; Emtricitabine/tenofovir disoproxil fumarate; Raltegravir
Varenicline Partial Nicotine Agonist, Smoking Cessation Aid Nicotine Dependence (2015) Bupropion
Venlafaxine Antidepressant, Serotonin/Norepinephrine Reuptake Inhibitor/Antagonist SNRIs (2012) Bupropion; Duloxetine
Nicotine replacement therapy (NRT), combination Smoking Cessation Aid Nicotine Dependence (2015) Combination NRT (nicotine patches + any short-acting NRT product) Bupropion; Varenicline
Duloxetine Antidepressant, Serotonin/Norepinephrine Reuptake Inhibitor/Antagonist Diabetic Neuropathy (2018) Bupropion; Venlafaxine
Sevelamer carbonate Phosphate Binder Phosphate Binders (2018) For patients on dialysis who cannot use calcium-based phosphate binders due to hypercalcemia Calcium
Topiramate Anticonvulsant, Miscellaneous Antiepileptic Medications (2014) Carbamazepine; Divalproex; Lamotrigine; Levetiracetam; Phenytoin
Phenytoin Anticonvulsant, Hydantoin Antiepileptics (2014) Carbamazepine; Divalproex; Lamotrigine; Levetiracetam; Topiramate
Levetiracetam Anticonvulsant, Miscellaneous Antiepileptics (2014) Carbamazepine; Divalproex; Lamotrigine; Phenytoin; Topiramate
Lamotrigine Anticonvulsant, Miscellaneous Antiepileptics (2014) Carbamazepine; Divalproex; Levetiracetam; Phenytoin; Topiramate
Divalproex Anticonvulsant, Miscellaneous ER Lithium & Divalproex (2012) Carbamazepine; Lamotrigine; Levetiracetam; Phenytoin; Topiramate
Ceftriaxone Injection Antibiotic, Cephalosporin **COMING SOON** Cefixime
Cefixime Antibiotic, Cephalosporin **COMING SOON** For outpatient treatment of gonorrhea Ceftriaxone Injection
Hydrochlorothiazide Antihypertensive; Thiazide Diuretic Diuretics (2014) Chlorthalidone
Sertraline Antidepressant, Selective Serotonin Reuptake Inhibitor Citalopram; Escitalopram; Fluoxetine; Paroxetine
Paroxetine Antidepressant, Selective Serotonin Reuptake Inhibitor SSRIs (2019) Citalopram; Escitalopram; Fluoxetine; Sertraline
Escitalopram Antidepressant, Selective Serotonin Reuptake Inhibitor SSRIs (2019) Citalopram; Fluoxetine; Paroxetine; Sertraline
Lorazepam Benzodiazepine Alcohol Withdrawal Syndrome (2015) Clonazepam
Corticosteroid (Topical) - Low potency Topical Corticosteroids *Any product* Corticosteriods (Topical) - High potency (Class I and II); Corticosteroid (Topical) - Intermediate potency
Tacrolimus Calcineurin Inhibitor; Immunosuppressant Agent; Topical Skin Product Atopic Dermatitis (2020) Corticosteriods (Topical) - High potency (Class I and II); Corticosteroid (Topical) - Intermediate potency; Corticosteroid (Topical) - Low potency; Moisturizers (both cream- AND petroleum-based)
Moisturizers (both cream- AND petroleum-based) Skin and Mucous Membrane Agent, Miscellaneous; Topical Skin Product Atopic Dermatitis (2020) Corticosteriods (Topical) - High potency (Class I and II); Corticosteroid (Topical) - Intermediate potency; Corticosteroid (Topical) - Low potency; Tacrolimus
Corticosteroid (Topical) - Intermediate potency Topical Corticosteroids *Any product* Corticosteriods (Topical) - High potency (Class I and II); Corticosteroid (Topical) - Low potency
Corticosteriods (Topical) - High potency (Class I and II) Topical Corticosteroids Psoriasis (2018) Corticosteroid (Topical) - Intermediate potency; Corticosteroid (Topical) - Low potency
Atomoxetine Norepinephrine Reuptake Inhibitor, Selective ADHD (2020) Dextroamphetamine / Amphetamine (immediate release); Dextroamphetamine / Amphetamine (long-acting); Methylphenidate (immediate release); Methylphenidate (long-acting)
Dextroamphetamine / Amphetamine (long-acting) Central Nervous System Stimulant Pediatric use only Dextroamphetamine and amphetamine (immediate release)
Dextroamphetamine / Amphetamine (immediate release) Central Nervous System Stimulant Pediatric use only Dextroamphetamine and amphetamine (long-acting)
Naproxen Nonsteroidal Anti-Inflammatory Drug NSAIDs (2014) Diclofenac; Ibuprofen; Indomethacin
Sulindac ===REMOVED from NCF=== (see Diclofenac, Ibuprofen, Indomethacin, Meloxicam, Naproxen) NSAIDs in Chronic Pain (2014) Removed May 2014 Diclofenac; Ibuprofen; Indomethacin; Meloxicam; Naproxen
Meloxicam Nonsteroidal Anti-Inflammatory Drug NSAIDs (2014) Diclofenac; Ibuprofen; Indomethacin; Naproxen
Indomethacin Nonsteroidal Anti-Inflammatory Drug NSAIDs (2014) Diclofenac; Ibuprofen; Meloxicam; Naproxen
Ibuprofen Nonsteroidal Anti-Inflammatory Drug NSAIDs (2014) Diclofenac; Indomethacin; Meloxicam; Naproxen
Amlodipine Antihypertensive; Calcium Channel Blocker, Dihydropyridine Calcium Channel Blockers (2014) Diltiazem
Verapamil ===REMOVED from NCF=== (see Diltiazem) Calcium Channel Blockers (2014) Removed August 2014 Diltiazem
Carbamazepine Anticonvulsant, Miscellaneous Antiepileptics (2014) Divalproex; Lamotrigine; Levetiracetam; Phenytoin; Topiramate
Bictegravir/emtricitabine/tenofovir alafenamide Antiretroviral, Integrase Inhibitor (Anti-HIV) HIV Treatment (2019) Dolutegravir/abacavir/lamivudine; Emtricitabine/tenofovir disoproxil fumarate; Raltegravir
Tamsulosin Alpha1 Blocker Benign Prostatic Hypertrophy (2016) Doxazosin; Prazosin
Terazosin ===REMOVED from NCF=== (see Doxazosin, Prazosin, Tamsulosin) Prazosin in PTSD (2012) Removed Jan 2012 Doxazosin; Prazosin; Tamsulosin
Prazosin Alpha1 Blocker; Antihypertensive PTSD Indication (2012) Doxazosin; Tamsulosin
Lopinavir / Ritonavir (Kaletra®) ===REMOVED from NCF=== (see Emtricitabine/tenofovir) HIV PrEP (2018) Removed August 2013 Emtricitabine / Tenofovir (Truvada®) - (**REMS drug**)
Raltegravir Antiretroviral, Integrase Inhibitor (Anti-HIV) HIV Treatment (2019) For (1) HIV Post-Exposure Prophylaxis (with emtricitabine/ tenofovir DF) or (2) HIV Treatment (with emtricitabine/tenofovir DF) in patients with contraindications for 1st line anti-HIV agents Emtricitabine/tenofovir disoproxil fumarate
Dolutegravir Antiretroviral, Integrase Inhibitor (Anti-HIV) HIV Updates (2020) For HIV treatment in pregnant patients Emtricitabine/tenofovir disoproxil fumarate; Raltegravir
Citalopram Antidepressant, Selective Serotonin Reuptake Inhibitor SSRIs (2019) Escitalopram; Fluoxetine; Paroxetine; Sertraline
Estrogen vaginal cream Estrogen Derivative NPTC Meeting Update (May 2018) *Any product* Estradiol tablets
Conjugated estrogen vaginal cream, (Premarin) ===REMOVED from NCF=== (see Estrogen vaginal cream) NPTC Meeting Update (May 2018) Removed May 2018 Estrogen vaginal cream
Adalimumab -OR- Etanercept (can choose either product) Antirheumatic, Disease Modifying; Tumor Necrosis Factor (TNF) Blocking Agent TNF Inhibitors (2016) ONLY In consultation with a rheumatologist Etanercept -OR- Adalimumab (can choose either product)
Rifapentine Antitubercular Agent Rifapentine (2013) Ethambutol; Isoniazid; Pyrazinamide; Rifampin
Rifampin Antitubercular Agent Ethambutol; Isoniazid; Pyrazinamide; Rifapentine
Pyrazinamide Antitubercular Agent Ethambutol; Isoniazid; Rfapentine ; Rifampin
Isoniazid Antitubercular Agent Ethambutol; Pyrazinamide; Rifampin; Rifapentine
Oral contraceptive pill, progestin only Contraceptive *Any product* Etonogestrel; Implant; Intrauterine Device; Levonorgestrel
Mometasone / Formoterol (Dulera®) ===REMOVED from NCF=== (see Fluticasone/salmeterol) LABAs (2019) Removed June 2019 Fluticasone/salmeterol
Fluticasone / Salmeterol (Advair®) ===REMOVED from NCF=== (see immediately below) Removed Oct 2012 Fluticasone/salmeterol
Sofosbuvir/velpatasvir (Epclusa®) Antihepaciviral HCV Treatment (2018) Glecaprevir/pibrentasvir (Mavyret®); Ledipasvir/sofosbuvir (Harvoni®)
Ledipasvir/sofosbuvir (Harvoni®) Antihepaciviral HCV Treatment (2018) Glecaprevir/pibrentasvir (Mavyret®); Sofosbuvir/velpatasvir (Epclusa®)
Glyburide ===REMOVED from NCF=== (see Glipizide) Sulfonylureas (2015) Removed May 2015 Glipizide
Glucose, Oral Antidote Glucagon Delivery Devices (2021) Any formulation Glucagon
Aripiprazole lauroxil Antipsychotic, Atypical (Second Generation) - Injectable Long-Acting Injectable Antipsychotics (2020) Injectable Haloperidol decanoate
Chlorthalidone Antihypertensive; Thiazide-Related Diuretic Diuretic Agents (2014) Hydrochlorothiazide
Sulfasalazine 5-Aminosalicylic Acid Derivative Hydroxychloroquine; Leflunomide; Methotrexate
Methotrexate Antineoplastic Agent; Antirheumatic; Disease Modifying; Immunosuppresant Agent Non-biologic DMARDs (2016) Hydroxychloroquine; Leflunomide; Sulfasalazine
Leflunomide Antirheumatic, Disease Modifying Non-biologic DMARDs (2016) Hydroxychloroquine; Methotrexate; Sulfasalazine
Diclofenac Nonsteroidal Anti-Inflammatory Drug NSAIDs (2014) *Any formulation* Ibuprofen; Indomethacin; Meloxicam; Naproxen
Insulin glargine (Lantus®) ===REMOVED from NCF=== (see Insulin detemir) NPTC Meeting Update (May 2019) Removed May 2019 Insulin detemir (Levemir®)
Insulin detemir (Levemir®) Insulin, Long-Acting Insulins (2015) *Branded product*; Pen Device Insulin glargine (Lantus®)
Intrauterine device, levonorgestrel Contraceptive, Progestin Contraception (2016) *Any product*; For use by a skilled and privileged provider Intrauterine device, copper
Intrauterine device, copper Contraceptive Contraception (2016) *Any product*; For use by a skilled and privileged provider Intrauterine device, levonorgestrel
Ethambutol Antitubercular Agent Isoniazid; Pyrazinamide; Rifampin; Rifapentine
Isosorbide dinitrate ===REMOVED from NCF=== (see Isosorbide mononitrate) Removed Aug 2013 Isosorbide mononitrate
Nitroglycerin patch Antianginal Agent; Antidote, Extravasation; Vasodilator Isosorbide mononitrate; Nitroglycerin 0.4 milligrams; Sublingual
Nitroglycerin 0.4 milligrams, sublingual Antianginal Agent; Antidote, Extravasation; Vasodilator Isosorbide mononitrate; Nitroglycerin patch
Polyethylene glycol Laxative, Osmotic Irritable Bowel Syndrome (2018) *Any product* Lactulose
Rifaximin Antibiotic, Rifamycin Hepatic Encephalopathy (2020) After failure of, or intolerance to, lactulose monotherapy as indicated for hepatic encephalopathy Lactulose
Glecaprevir/pibrentasvir (Mavyret®) Antihepaciviral HCV Treatment (2018) Ledipasvir/sofosbuvir (Harvoni®); Sofosbuvir/velpatasvir (Epclusa®)
Hydroxychloroquine Antimalarial Non-biologic DMARDs (2016) Leflunomide; Methotrexate; Sulfasalazine
Ulipristal Contraceptive; Progestin Receptor Modulator Contraception (2016) Levonorgestrel (Plan B One-Step®)
Dedicated emergency contraceptive ===REMOVED from NCF=== (see Levonorgestrel; Ulipristal) Contraception (2016) Removed Sept 2013 Levonorgestrel (Plan B One-Step®); Ulipristal
Clonazepam Benzodiazepine Alcohol Withdrawal Syndrome (2015) Lorazepam
Angiotensin receptor blocker ===REMOVED from NCF=== (see Losartan) Angiotensin II Receptor Antagonists (2014) Removed April 2012 Losartan
Medroxyprogesterone, oral Contraceptive; Progestin Polycystic Ovarian Syndrome (2017) Medroxyprogesterone acetate, injection; Oral contraceptive pill, progestin only
Medroxyprogesterone acetate, injection Contraceptive, Progestin (Injection/Depot) Contraception (2016) Medroxyprogesterone, oral; Oral contraceptive pill, progestin only
Propylthiouracil Antithyroid Agent; Thioamide Hyperthyroidism (2021) Methimazole
Methylphenidate (long-acting) Central Nervous System Stimulant Pediatric use only Methylphenidate (immediate release)
Methylphenidate (immediate release) Central Nervous System Stimulant Pediatric use only Methylphenidate (long-acting)
Atenolol Antihypertensive; Beta-Blocker, Beta1 Selective Beta Blockers (2014) Metoprolol; Propranolol
Fluticasone/salmeterol Beta2 Agonist, Long-Acting; Corticosteroid, Inhalant LABAs (2019) Mometasone (Asmanex®)
Oral contraceptive pill, monophasic: 30-35mcg EE (medium) Contraceptive *Any product* Monophasic: 20mcg EE (low) ; Oral contraceptive pill
Oral contraceptive pill, monophasic: 20mcg EE (low) Contraceptive *Any product* Monophasic: 30-35mcg EE (medium); Oral contraceptive pill
Oral contraceptive pill, triphasic Contraceptive *Any product* Monophasics ; Oral Contraceptive Pill
Naltrexone, oral Antidote; Opioid Antagonist Alcohol Use Disorders (2015) Naloxone
Buprenorphine-naloxone (**REMS drug**) Analgesic, Opioid; Analgesic, Opioid Partial Agonist Opioid Use Disorder (2018) **See REMS here** Exit Disclaimer: You Are Leaving www.ihs.gov  Naloxone
Isosorbide mononitrate Antianginal Agent; Vasodilator Nitroglycerin 0.4 Milligrams; Sublingual; Nitroglycerin patch
Imipramine ===REMOVED from NCF=== (see Nortriptyline) Antidepressant Use in Chronic Pain (2014) Removed May 2014 Nortriptyline
Amitriptyline Antidepressant, Tricyclic Antidepressants in Pain Mgmt (2014) Nortriptyline
Etonogestrel, implant Contraceptive; Progestin Contraception (2016) For use by a skilled and privileged provider Oral contraceptive pill, progestin only
Oxybutynin, Immediate-release Antispasmodic Agent, Urinary Antimuscarinics (2019) Oxybutynin, Extended-release
Trospium ===REMOVED from NCF=== (see Oxybutynin ER, IR) Antimuscarinics (2019) Removed Feb 2019 Oxybutynin, Extended-release; Oxybutynin, Immediate-release
Oxybutynin, Extended-release Antispasmodic Agent, Urinary Antimuscarinics (2019) Oxybutynin, Immediate-release
Lactulose Ammonium Detoxicant; Laxative, Osmotic Cirrhosis & Complications (2015) Polyethylene glycol
Atorvastatin Antilipemic Agent, HMG-CoA Reductase Inhibitor Dyslipidemia Guideline Review (2014) Pravastatin; Rosuvastatin; Simvastatin
Doxazosin Alpha1 Blocker; Antihypertensive Benign Prostatic Hypertrophy (2016) Prazosin; Tamsulosin
Methimazole Antithyroid Agent; Thioamide Hyperthyroidism (2021) Propylthiouracil
Ranitidine* Histamine H2 Antagonist GERD & PUD (2018) *(April 1, 2020) The Food and Drug Administration has recommended that all formulations of ranitidine be taken off the market due to contaminates of N-Nitrosodimethylamine (NDMA), a carcinogen, in ranitidine products. Exit Disclaimer: You Are Leaving www.ihs.gov  Proton Pump Inhibitor
Omeprazole (enteric coated) ===REMOVED from NCF=== (see Proton Pump Inhibitor) Long-Term Use of PPIs (2014) Removed Feb 2014 Proton Pump Inhibitor
Emtricitabine/tenofovir disoproxil fumarate Antiretroviral, Reverse Transcriptase Inhibitor, Nucleoside (Anti-HIV); Antiretroviral, Reverse Transcriptase Inhibitor, Nucleotide (Anti-HIV) HIV Pre-Exposure Prophylaxis (PrEP) (2018) For (1) Pre-Exposure HIV Prophylaxis, (2) Post-Exposure HIV Prophylaxis (with raltegravir) or (3) HIV Treatment (with raltegravir) in patients with contraindications for 1st line anti-HIV agents Raltegravir
Fluoxetine Antidepressant, Selective Serotonin Reuptake Inhibitor Sertraline
Serotonin 5-HT1 agonist (Triptan) Antimigraine Agent; Serotonin 5-HT 1B/1D Receptor Agonist Triptans (2016) Any two (2) triptan medications are required, one must be sumatriptan Sumatriptan
Umeclidinium/vilanterol Long-Acting Muscarinic Antagonist (LAMA) / Long-Acting Beta2 Agonist (LABA) LAMAs (2019) Tiotropium (Spiriva®)
Levonorgestrel (Plan B One-Step®) Contraceptive, Progestin Contraception (2016) *Branded product* Ulipristal
Bupropion Antidepressant, Dopamine/Norepinephrine-Reuptake Inhibitor; Smoking Cessation Aid Nicotine Dependence (2015) Varenicline; Venlafaxine
Apixaban Anticoagulant; Direct Oral Anticoagulant (DOAC); Factor Xa Inhibitor Direct Oral Anticoagulants (2017) Warfarin