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Chronic Pain

Chronic pain is persistent pain, occurring for more than 3 months, which can be either continuous or recurrent and of sufficient duration and intensity to adversely affect a patient's well-being, level of function, and quality of life. The cause of pain may not be removable or otherwise treated despite generally accepted medical interventions. Chronic pain is often subjective and may include physical (e.g., somatic, visceral, or neuropathic), psychological, social, and spiritual components.

The goal of chronic pain management is to safely and effectively reduce pain and improve function and quality of life. Complete eradication of chronic pain is an unrealistic expectation and should not be a goal for the patient or the provider. Multi-modal treatment therapies addressing the bio-psycho-social-spiritual needs of the patient should be employed as safe, best practice treatment options. Appropriately prescribing opioid medications and managing chronic pain are critically important within the Indian Health Service. In May 2023, IHS released the revised agency policy on Chronic Pain Management.

The patient-provider relationship is built on a shared understanding of a whole-person treatment approach. Patient preferences and values should be heard, understood and used to inform clinical decisions. Providers should carefully consider and ensure patients are aware of the expected benefits, risks, and alternatives to opioids before starting or continuing opioid therapy.

Resources

Motivational Interviewing Steps and Core Skills [PDF - 2.2 MB]

Motivational Interviewing in Managing Pain Exit Disclaimer: You Are Leaving www.ihs.gov  [PDF - 467 MB] — Providers Clinical Support System

Proper patient assessment is essential when deciding whether or not to initiate opioids for pain and if necessary, when determining the specific opioid, dose, and frequency to prescribe, and the duration of the initial prescription and follow-up intervals. Often, patients with a long history of a pain diagnosis and opioid medication therapy are inherited by providers with little to no historical information as to the origin of the injury, imaging, and other pertinent medical history. It is essential to perform a thorough chart review and obtain historical records from specialists and previous primary care providers. Periodic reassessment by obtaining a completely new and thorough pain history with appropriate imaging may help providers and patients to develop and update treatment plans.

A patient's pain score is just one of several measurements of successful chronic pain treatment. "Zero" pain is not realistic, achievable or desirable. Small reductions in pain are considered major successes if they lead to increased function. Realistic functional goals should be set collaboratively between the prescriber and patient and re-visited routinely. Clinicians should strive to find individualized, objective measures for each pain patient. Pain experts recommend a function-based treatment strategy that focuses on restoring some or all of the pain patient’s normal activities.

Functional assessment tools measure essential characteristics associated with in chronic pain populations and allow the patient a medium in which to express critical facts about how intense the pain is, what part of the body it originates, the type of pain, and how it impacts their quality of life. These tools help to monitor the patient's progress and prevent medication misuse.

A functional assessment should be completed at baseline, annually, when considering dose or frequency changes, and when deemed clinically appropriate. The provider should learn what patient-specific activities have been impacted because of chronic pain and then establish weekly or monthly objectives for restoring these activities using a multi-modal treatment approach. In collaboration with the patient, the provider may consider creating a scale where the lowest end is the patient's ability to engage in only one of their normal activities (e.g., sleeping) and the highest end would be the ability to engage in all their activities (e.g., sleeping, eating, working, recreation, etc.).

The table below outlines individual treatment modalities for managing chronic pain.

Treatment Option Description
Pharmacological management

…includes: anticonvulsants (gabapentin or pregabalin for neuropathic pain); antidepressants (amitriptyline, nortriptyline, venlafaxine, or duloxetine for neuropathic pain); N-methyl-D-aspartate (NMDA) receptor antagonists; nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, indomethacin, meloxicam, naproxen, diclofenac (oral, gel, or patches); muscle relaxants such as cyclobenzaprine, baclofen, metaxalone; and topical agents such as lidocaine patches.

Opioids (such as hydrocodone, morphine, codeine, or oxycodone) should be utilized cautiously, sparingly, and last line for very short duration. Opioid medications should be utilized primarily for post-surgical and acute traumatic pain management for a very short duration (weeks to less than 3 months); chronic pain syndromes that persist beyond 3 months should not be treated with opioids due to opiate-induced hyperalgesia, tolerance and dependence, iatrogenic addiction, diversion, overdose, reduction in quality of life and functionality, and general ineffectiveness for adequate pain control.

Avoid the muscle relaxant soma (carisoprodol). Carisoprodol is a pro-drug that metabolizes into meprobamate, which is a schedule IV depressant having physical and psychological addictive properties and exhibits many barbiturate-like pharmacological effects.

Exercise extreme caution prescribing opioids concomitantly with other Central Nervous System depressants such as benzodiazepines (alprazolam, lorazepam, clonazepam, diazepam) and sleep hypnotics (zolpidem and eszopiclone). These combinations of medications are referred to as the "deadly trifecta" or "terrible triad" due to the additive respiratory depression and potential for inadvertent overdose at medically prescribed doses. Alcohol use with any of these agents also poses a morbidity and mortality risk. Avoid these medications in patients with a history or current alcohol use, including social drinking.

Benzodiazepines should not be used for symptom management of chronic pain syndromes and are contraindicated in patients with history of or current alcohol and substance abuse disorders; these are last-line agents for treatment of anxiety, in which psychotherapy and/or anti-depressants are first-line treatments.

Drugs listed above in bold are on the IHS National Core Formulary as of May 22, 2014.

Multimodal care …includes exercise, manual therapy, dry needling, pain science education, mind body strategies, and modalities.
Joint blocks (via injections) and nerve or nerve root blocks …may be useful for relief of some types of pain.
Epidural steroid injections …alleviate radicular (nerve root) pain.
Botulin injections … may be used as an adjunct in the treatment of piriformis syndrome, a type of sciatica.
Intrathecal (brain or spinal cord) drug therapies …include neurolytic (nervous tissue) blocks and injected steroids, ziconotide, and opioids. Effectiveness of neurolytic blocks is controversial.
Minimally invasive spinal procedures …alleviate pain from osteoporosis or fractures of the vertebrae.
Physical therapy …strengthening of the musculoskeletal system can improve chronic pain. Exercise causes the release of the body's natural pain neurochemicals (enkaphalins, dynorphines, and endorphins or "endogenous morphine") and has been proven to reduce stress, decrease depression and anxiety, and improve sleep.
Psychological treatment … includes one-on-one or group counseling, mindful cognitive behavioral therapy, biofeedback, and relaxation therapy. Therapy should focus on cognitive reframing of pain perception and development of healthy primary coping skills. Referrals for screening and treatment of underlying mental health disorders such as depression, anxiety, and post-traumatic stress disorder is essential for pain symptom management. Pain symptom perception is exacerbated by uncontrolled and untreated mental health disorders.
Acupuncture …may be used in conjunction with conventional therapy to relieve non-inflammatory lower back pain.
Electrical nerve stimulation … through the skin or with an implanted device can treat nerve injuries or radicular (nerve root) pain for patients who've not responded to other therapies.
Trigger point injections …used to ease chronic pain in tissue surrounding muscle that does not respond to other treatment. Effectiveness is controversial.
Ablation (burning or abrasion) …of nerves or nerve roots should be a last resort treatment for intractable pain non-responsive to traditional therapies.
Alternative Medicine Therapy …encourage Tai Chi, Chi Quong, Zen Meditation, and/or Yoga practices as adjunctive treatment.

References

Pain Management Best Practices Inter-Agency Task Force Report Exit Disclaimer: You Are Leaving www.ihs.gov  [PDF - 571 MB] — U.S. Department of Health and Human Services

Practice Guidelines for Chronic Pain Management: An Updated Report by the American Society of Anesthesiologists Task Force on Chronic Pain Management and the American Society of Regional Anesthesia and Pain Medicine.” Exit Disclaimer: You Are Leaving www.ihs.gov  Anesthesiology 112(4) (2010): 1–24.

The continuation or modification of chronic opioid therapy should be contingent on the evaluation of the patient's progress toward treatment objectives and goals. The risk of adverse events, including diversion and overdose, and quality of life should continue to be monitored and considered. Regardless, safe and effective non-opioid and/or non-pharmacologic options should be considered and utilized in a patients' pain management plan based on an individualized assessment considering the diagnosis, access to treatment, and unique needs of the patient.

Consider tapering to lowest effective dose, which may include discontinuation, when:

  • Patient requests dosage reduction or discontinuation
  • Pain, function, and quality of life are not meaningfully improved
  • Patient has been treated with opioids for a prolonged period (e.g., years), and current benefit-harm balance is unclear
  • Higher opioid dose is not providing additional benefits
  • Provider suspects opioid misuse
  • Patient experiences an overdose or other serious event (e.g., hospitalization, injury) or has warning signs for an impending event such as confusion, sedation, or slurred speech
  • Patient is prescribed other high-risk medications (e.g., benzodiazepines) or has medical conditions, such as lung disease, sleep apnea, liver disease, kidney disease, gait disturbances, advanced age, etc., that increase risk for adverse outcomes

Opioids should not be rapidly tapered or discontinued suddenly due to risk of significant opioid withdrawal. An individualized care plan should be created with the patient to reduce risk of acute withdrawal, worsened pain syndrome, anxiety, depression, suicidal ideation, self-harm, weakened trust with the health system, and patients seeking opioids from illicit sources.

  • Interdisciplinary case management, some examples:
    • Pharmacists may help prescribers manage patient tapers, monitor response, manage withdrawal symptoms, and provide patient education
    • Behavioral health team members may assist with patient education and behavioral strategies surrounding anxiety with an opioid taper
  • Documentation of patient education on the risk of overdose with the abrupt return to a previously prescribed higher dose of opioids
  • Naloxone should be provided
  • Education of harm reduction strategies and available services
  • If physical dependence is suspected, the discontinuation of opioid treatment should not mark the end of treatment, but rather, other modalities should be utilized, either through direct care or referral to other health care specialists
  • Slow and gradual tapers should help to lessen withdrawal symptoms, and withdrawal should be managed by the provider or pain specialist

Resources