Skip to site content

Dental Problems Have Been Reported with Medicines Containing Buprenorphine that are Dissolved in the Mouth

Dental problems have been reported with medicines containing buprenorphine that are dissolved in the mouth (e.g., dissolving tablets and films). The dental problems, including tooth decay, cavities, oral infections, and loss of teeth, can be serious and have been reported even in patients with no history of dental issues. Reports indicate that one or more teeth may be affected and tooth extraction/removal is the most common treatment.

Despite these risks, buprenorphine is an important treatment option for opioid use disorder (OUD) and pain, and the benefits of these medicines clearly outweigh the risks.

The complete Drug Safety Communication can be viewed on the FDA website Exit Disclaimer: You Are Leaving .

Report adverse events involving this or other medicines to the MedWatch program as recommended in the Indian Health Manual and include “IHS” in the reporter section (section G).

Instructions for reporting can be found online at the NPTC Pharmacovigilance website.