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Electronic Prescriptions of Controlled Substances

The Drug Enforcement Administration has issued an interim final rule allowing practitioners the option of writing prescriptions for controlled substances (Schedules II through V) electronically and permitting pharmacies to receive, dispense, and archive electronic prescriptions. (21 C.F.R. Parts 1300, 1304, 1306, and 1311) The rule became effective June 1, 2010. This new regulation modifies existing regulations, which remain in force. The prescribing practitioner must use an electronic health record application (software) that complies with the interim final rule, and a qualified third party must verify the application’s compliance with the rule. For a copy of the interim final rule and for questions and answers about it, visit the Office of Diversion Control Exit Disclaimer: You Are Leaving .


Indian Health Service. Office of Management Services. Indian Health Manual. Rockville, MD: U.S. Department of Health and Human Services, 2009.

Drug Enforcement Administration. Office of Diversion Control. Pharmacist’s Manual: An Informational Outline of the Controlled Substances Act (2020), Exit Disclaimer: You Are Leaving  [PDF - 1 MB] .

“Dispensing Controlled Substances for the Treatment of Pain; Policy Statement,” Exit Disclaimer: You Are Leaving  [PDF - 140KB] Federal Register, Vol. 71, No. 172 (September 6, 2006), pp. 52,716-52,723.

Office of Diversion Control, Exit Disclaimer: You Are Leaving  Drug Enforcement Administration.