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Multiple Prescriptions of Schedule II Drugs

Drug Enforcement Administration regulations allow practitioners to provide individual patients with multiple prescriptions, to be filled sequentially, for the same Schedule II controlled substance, with such multiple prescriptions having the combined effect of allowing a patient to receive over time up to a 90-day supply of that controlled substance. (21 C.F.R. Part 1306) Among the requirements are that each prescription issued have a “legitimate medical purpose” and that doctors include written instructions on each prescription. For questions and answers about the multiple prescription rule, visit the Office of Diversion Control Exit Disclaimer: You Are Leaving .


Indian Health Service. Office of Management Services. Indian Health Manual. Rockville, MD: US Department of Health and Human Services, 2009.

Drug Enforcement Administration. Office of Diversion Control. Practitioner’s Manual: An Informational Outline of the Controlled Substances Act (2006 Edition). Exit Disclaimer: You Are Leaving  By Joseph T. Rannazzisi and Mark W. Caverly. Washington, DC: US Department of Justice, 2006.

“Dispensing Controlled Substances for the Treatment of Pain; Policy Statement,” Exit Disclaimer: You Are Leaving  [PDF - 140KB] Federal Register, Vol. 71, No. 172 (September 6, 2006), pp. 52,716–52,723.

Office of Diversion Control. Exit Disclaimer: You Are Leaving  Drug Enforcement Administration.