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Diabetes Standards of Care & Clinical Practice Resources


Neuropathy is a common complication of diabetes affecting multiple organ systems, and is a significant cause of morbidity and mortality. Poor blood glucose control and smoking can significantly increase the risk of neuropathy and its complications. There is no specific treatment for the nerve damage associated with diabetic neuropathy. Improving glycemic control may slow progression, but does not reverse nerve loss.

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Clinical Practice Recommendations

Recommendations for Neuropathy

  • Screen patients with diabetes for distal symmetric polyneuropathy (DPN) and autonomic neuropathy at diabetes diagnosis, and then at least annually.
  • Consider treatment to reduce neuropathic pain.

There are two main types of diabetic neuropathy: distal symmetric polyneuropathy and autonomic neuropathy.

  • Distal symmetric polyneuropathy, often referred to as peripheral neuropathy, most commonly affects the feet and legs in people with diabetes, and is the major cause of lower extremity problems, including pain, ulceration, and amputations. See the Foot Care Standard of Care for recommendations on DPN screening, management, and referral.
  • Autonomic neuropathy is responsible for various cardiovascular, gastrointestinal, and genitourinary clinical problems that can have significant associated morbidity and increased mortality rates. This form of neuropathy can manifest as: resting tachycardia, exercise intolerance, orthostatic hypotension, constipation, gastroparesis, erectile dysfunction, and sudomotor dysfunction. Screening consists of assessing signs and symptoms of autonomic dysfunction when taking the patient's history and during physical examination. Treatments are available for symptomatic autonomic neuropathy that may improve quality of life, but these treatments do not alter the disease process. See the resources below for sources that contain comprehensive discussions of this topic.

Patient Education Resources

Diabetic Neuropathy Exit Disclaimer: You Are Leaving 

National Institute of Diabetes and Digestive and Kidney Diseases