Diabetes Standards of Care and Resources for Clinicians and Educators
Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH) represent a spectrum of diseases from simple fatty liver (steatosis) to steatosis with inflammation, necrosis, and cirrhosis. NAFLD occurs in people who drink little or no alcohol and affects all age groups. NASH represents the more severe end of this spectrum, and it is associated with liver disease that progresses to fibrosis and cirrhosis. The etiology of NASH and the cellular basis for fat accumulation in the liver are unclear. Most patients with NASH are obese and have associated type 2 diabetes, hypertension, dyslipidemia, and insulin resistance.