Diabetes Standards of Care & Clinical Practice Resources
Aspirin and Other Antiplatelet Therapy
Antiplatelet therapy, including aspirin and clopidogrel, may be used to reduce the risk of cardiovascular disease (CVD) events in appropriate patients with diabetes.
Aspirin or Other Antiplatelet Therapy Sections
Quickly jump to a section on this page by clicking on one of the links below.
- Section 1 – Clinical Practice Recommendations: Aspirin or Other Antiplatelet Therapy
- Section 2 – Clinician and Educator Resources: Aspirin or Other Antiplatelet Therapy
- Section 3 – Patient Education Resources: Aspirin or Other Antiplatelet Therapy
Clinical Practice Recommendations
- Patients with a history of Atherosclerotic Cardiovascular Disease (ASCVD)* should receive aspirin 75-162mg who are not at increased risk of bleeding.
- If allergic to aspirin, consider clopidogrel 75mg daily.
- Consider aspirin 75-162mg in patients with increased risk of ASCVD, (e.g., age ≥ 50 years and one or more risk factors**), who are not at increased risk of bleeding.
- Aspirin is not recommended in patients at lower risk of ASCVD, (e.g., age < 50 years with no other major ASCVD risk factors**).
* ASCVD is atherosclerosis affecting the vasculature of any of the following: the heart, periphery (e.g., legs, carotids), and the brain (e.g., stroke, transient ischemic attack).
** Risk factors include: family history of premature ASCVD, hypertension, dyslipidemia, smoking, or albuminuria.
Clinician and Educator Resources
IHS Division of Diabetes Treatment and Prevention
American Diabetes Association. 10. Cardiovascular disease and risk management: Standards of Medical Care in Diabetes 2021 Diabetes Care 2021;44(Suppl.1):S125-S150. doi:10.2337/dc21-S010
American Diabetes Association
American College of Cardiology/American Heart Association
Center for American Indian Health Research – College of Public Health
University of Oklahoma Health Sciences Center
U.S. Preventive Services Task Force
Patient Education Resources
American Heart Association
HHS Million Hearts Initiative
National Institute of Diabetes and Digestive and Kidney Diseases