Diabetes Standards of Care and Resources for Clinicians and Educators
Aspirin and Other Antiplatelet Therapy
Antiplatelet therapy, including aspirin and clopidogrel, may be used to reduce the risk of cardiovascular disease events in appropriate patients with diabetes.
Recommendations for Aspirin and Other Antiplatelet Therapy
Secondary Prevention
Prescribe aspirin 75-162 mg in patients with or without diabetes who have a history of atherosclerotic cardiovascular disease (ASCVD1), unless contraindicated.
Consider clopidogrel 75 mg daily, if allergic to aspirin.
Primary Prevention
Consider aspirin 75-162 mg/day in patients with diabetes aged 50-70 years and:
An increased risk of ASCVD (e.g., age ≥50 years and one or more risk factors2); and
Not at increased risk for bleeding
1 ASCVD is atherosclerosis affecting the vasculature that results in diseases of any of the following: the heart (e.g., myocardial infarction, angina), the brain (e.g., stroke, transient ischemic attack), and the lower extremities (e.g., peripheral artery disease, limb ischemia).
2 Risk factors include: family history of premature ASCVD, hypertension, dyslipidemia, smoking, chronic kidney disease, or albuminuria.
Clinician and Educator Resources
Featured Aspirin and Other Antiplatelet Therapy Resources
