Diabetes Standards of Care and Resources for Clinicians and Educators

Who to Screen

• Adults 18 years and older, including people with diabetes, at least once for HCV infection, regardless of their risk factors.
• All pregnant women, regardless of age, during each pregnancy.
• People at higher risk of HCV exposure (see CDC Recommendations for Hepatitis C Screening Among Adults – United States, 2020). Exit Disclaimer: You Are Leaving www.ihs.gov 

How to Screen

How to Diagnose Chronic HCV Infection

• For individuals with a positive HCV antibody screening test result, perform the laboratory-based HCV RNA PCR test to confirm the presence of HCV.
  • The presence of HCV indicates active infection. These individuals should be referred for direct acting anti-viral (DAA) agents treatment.
  • The absence of HCV indicates no active infection.
• For individuals with a negative HCV antibody test result who might have been exposed to HCV within the previous 6 months, perform an HCV RNA PCR or follow-up HCV antibody test at least 6 months after exposure.

Treatment

• DAA treatments cure more than 90% of chronic HCV infections.
• The Indian Health Service National Core Formulary Exit Disclaimer: You Are Leaving www.ihs.gov  has several U.S. Food and Drug Administration-approved DAA therapies.
• Chronic HCV infection treatment guidance can be found at HCV Guidelines.org Exit Disclaimer: You Are Leaving www.ihs.gov  from the American Association for the Study of Liver Diseases and Infectious Diseases Society of America.

Monitoring

• Monitor blood sugar levels during and after DAA treatment.
  • Patients with diabetes taking insulin or sulfonylurea sometimes develop hypoglycemia, which may require adjustments to the doses of these medications. In some circumstances, patients with diabetes taking DAA agents develop hyperglycemia.
  • Patients without diabetes taking DAA agents can develop new-onset diabetes.