Individuals with alcohol and drug abuse disorders often present with wide fluctuations in their blood glucose in part due to inconsistent lifestyle behaviors as well as the physiological responses to alcohol and drugs.
Alcohol consumption causes a decrease in glucose production from the liver which may result in hypoglycemia. Hypoglycemia can occur shortly after drinking alcohol and can occur for up to 24 hours after ingestion. Patients are at increased risk for hypoglycemia when they consume alcohol on an empty stomach, skip meals, and/or take insulin or any other medications that increase insulin secretion.
Substance abuse with stimulants such as methamphetamine and/or cocaine may increase cortisol levels in the body. Increased cortisol levels inhibit endogenous insulin secretion contributing to hyperglycemia. Poor adherence to prescribed medications may also increase the risks of developing severe hyperglycemia. Stimulants and sedatives can also increase or decrease appetite and diminish awareness of hypoglycemia.